Citrinin pathway

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August undefined, 2024

WebMar 1, 2016 · The pathway rules out alternatives involving intramolecular rearrangements, and fully defines the molecular steps for the first time and … WebUV-Vis scan and UPLC detection showed that disruption of Mrhst4 significantly increased the MonAzPs yields, and citrinin content was dramatically enhanced during the tested period. RT-qPCR results showed that the absence of Mrhst4 significantly increased the relative expression of citrinin biosynthetic pathway genes including pksCT, mrl1, mrl2 ...

Toxins Free Full-Text Biomarkers of Deoxynivalenol, Citrinin ...

WebDec 17, 2015 · The pathway involves the synthesis of an unreduced trimethylated pentaketide 10 by a non-reducing polyketide synthase (nrPKS) known as CitS. Reductive … WebOct 1, 2024 · The citrinin pathway belongs to the former as it is present in many Penicillium, Aspergillus, and Monascus species [30, 44, 45]. However, the biosynthetic gene cluster of Monascus azaphilone pigments is limited in the Monascus genera. The biosynthetic process of secondary metabolites forms a cluster or non-clustered gene … how to stop mic from echoing windows 11

Investigation of Citrinin and Pigment Biosynthesis Mechanisms …

WebJun 28, 2024 · Citrinin targets the kidney, resulting in teratogenicity, carcinogenicity, and mutagenicity. Therefore, decreasing the content of citrinin is becoming a necessity that should be addressed as soon as possible. This study included a comprehensive transcriptomic analysis to elucidate the citrinin synthesis pathway in M. purpureus. WebAbstract ：Two cDNA subtractive libraries of Monascus were constructed by suppression subtractive hybridization(SSH) andscreened of correlative genes from the citrinin biosynthetic pathway in Monascus species. All clones in the two libraries weresequenced and the results were analyzed by bioinformatic softwares. WebSep 29, 2011 · In this paper, we describe the cloning and characterization of a 43 kb genomic DNA region of M. aurantiacus, which codes for 16 of the assumed genes of the … how to stop mice eating hedgehog food

Isolation and characterization of the citrinin biosynthetic gene ...

The molecular steps of citrinin biosynthesis in fungi - PMC

WebFeb 21, 2024 · Citrinin is a toxic secondary metabolite of Penicillium citrinum and its contamination in many food items has been widely reported. However, research on the citrinin biosynthesis pathway and its regulation mechanism in P. citrinum is rarely reported. In this study, we investigated the effect of different carbon sources on citrinin production … WebFurthermore, citrinin activates some important factors involved in apoptosis, including p21-activated protein kinase 2 (PAK2) dependent pathways, caspase-3 and -9, c-Jun N-terminal kinase (JNK) and it raises reactive oxygen species (ROS) . Caspase-3 is famous as an executioner caspase in apoptosis. how to stop mice eating car wiresWebTo learn more about the citrinin biosynthetic pathway, a ctnG-replacement vector was constructed to disrupt ctnG with the hygromycin resistance gene as the selection marker, then transformed into M. aurantiacus Li AS3.4384 by a protoplast-PEG method. The citrinin content of three disruptants was reduced to about 50%, meanwhile pigment ... how to stop mice chewing plastic pipes

"WebMay 27, 2024 · In our bodies, toxins are detoxed and excreted through a few pathways. Routes of elimination include urine, stool, bile and through our skin. Other routes include tears and saliva but are negligible in the realm of detoxification. ... This prebiotic has been shown to bind to citrinin, which a wide variety of molds produce. Using a variety of ... " - Citrinin pathway

Citrinin pathway

Chemical Compositions and Experimental and Computational …

WebDec 16, 2024 · He, Y. Construction of a High-Efficiency Gene Knockout System of Monascus ruber M7 and Analysis of the Biosynthetic Pathway of Citrinin. Ph.D. Thesis, Huazhong Agricultural University, Wuhan, China, 2015; pp. 113–118. [Google Scholar] He, Y.; Cox, R.J. The molecular steps of citrinin biosynthesis in fungi. WebJun 1, 2007 · The mycotoxin CTN (citrinin), a natural contaminant in foodstuffs and animal feeds, has cytotoxic and genotoxic effects on various mammalian cells. CTN is known to cause cell injury, including apoptosis, but the precise regulatory mechanisms of CTN action, particularly in stem cells and embryos, are …

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WebJan 1, 2016 · Citrinin is a toxic secondary metabolite of Penicillium citrinum and its contamination in many food items has been widely reported. However, research on the citrinin biosynthesis pathway and its ... WebThe application of Monascus is restricted by citrinin. So, it is important to explore the synthetic pathway of citrinin to completely inhibit the production of citrinin. In our previous study, we found that the protein encoded by the ctnF gene has a significant similarity to fructose-2,6-bisphosphatase (F26BPase).

WebJun 28, 2024 · In addition, changes in transcription factor expression may also influence the network regulating the citrinin synthesis pathway in M. purpureus. Moreover, the yields of pigments produced by the ... WebMar 30, 2024 · The disruption of MPs biosynthesis pathway can increase the production of citrinin, which may be due to more initial and extension units for citrinin biosynthesis. This illustrated that blocking of citrinin or pigment biosynthesis could significantly cause a change in their production in M. purpureus , and there is a mutual regulation between ...

WebSep 29, 2011 · CIT is synthesized via the polyketide pathway [20]. It is generally known that three secondary metabolites, pigments, monacolin K, and citrinin, share a biochemical … WebThe citrinin was completely detoxified by prior incubation with 0.05% hydrogen peroxide for 30 min at room temperature, and the toxic compound (s) that resulted from heating citrinin at 100 degrees C were also detoxified upon reheating it with hydrogen peroxide.

WebApr 11, 2024 · Damage to the reproductive system is the key factor leading to male infertility. Citrinin (CTN) is produced by Penicillium and Aspergillus in nature, and is definitely found in food and animal feed. Studies have revealed that CTN can cause damage to male reproductive organs and reduce fertility, but the mechanism of toxicity has not been …

WebJul 6, 2024 · Detox Pathway: Dietary Supplement: Food: Ochratoxin Sterigmatocystin T-2 toxin (trichothecene) Zearalenone Alternaniol DON (deoxynivalenol) Glucoronidation: … read books and earnWebJun 1, 2024 · Citrinin, a secondary metabolite, can pose serious risks to the environment and organisms, but its hepatotoxic mechanisms are still unclear. ... (ATP), activating AMPK pathway in L02 cells. Eventually, pretreatment with NAC, an ROS inhibitor, alleviates citrinin-induced cell cycle G2/M arrest and apoptosis by inhibiting ROS-mediated ER … read books amazon primeWebJun 18, 2009 · In vitro trials were conducted to evaluate the effect of Azadirachta indica (neem) extracts on mycelial growth, sporulation, morphology and ochratoxin A production by P. verrucosum and P. brevicompactum. The effect of neem oil extract from seeds and leaf was evaluated at 0.125; 0.25 and 0.5% and 6.25 and 12.5 mg/mL, respectively, in Yeast … read books aloud online freeWebJan 1, 1999 · Biosynthesis of citrinin and synthesis of its biogenetic precursors L. Colombo, C. Gennari, D. Potenza, C. Scolastico, F. Aragozzini, C. Merendi Chemistry 1980 … how to stop mice eating peasWebCitrinin, which is biosynthesized from a pentaketide through the acetate–malonate pathway with three C 1-sources, causes renal damage in swine. It has also been … how to stop mice from chewing car wiresWebYes. Some red yeast rice products contain a contaminant called citrinin, which is toxic and can damage the kidneys. In a 2024 analysis of 37 red yeast rice products, only one had citrinin levels below the maximum … read books and chillWebCitrinin C13H14O5 CID 54680783 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. … read books and earn money online